Elevated expression of SREBP-2 and ALR in human NASH tissue specimens
M Ilowski, S Liebhaber, S Gashi, J Leise, C Stielow, KW Jauch, M Rentsch, WE Thasler · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Nonalcoholic steatohepatitis (NASH) is a frequently recognized disease which is associated with obesity, insulin resistance and type 2 diabetes mellitus. Despite its frequent contribution, not much is known about the molecular mechanisms involved in NASH genesis. The expression of sterol regulatory element-binding protein 2 (SREBP-2) is an important factor in the pathogenesis of fatty livers. To examine the ability of regeneration of fatty livers, a RNA data base of specimens and corresponding RNA samples derived from patients with clinical and pathological proven NASH was set up and characterized. Aim of this s…
