TGF-β sensitizes heptocytes for damage by xenobiotics

Development and progression of chronic liver disease is associated with induction, activation and signal transduction of TGF-β. While its role in activation of hepatic stellate cells and subsequent extracellular matrix deposition is well established, not many details are currently known about TGF-β effects in hepatocytes. TGF-β causes oxidative stress by increasing reactive oxygen species and reducing cellular glutathione. mRNA expression profiling of mouse hepatocytes treated for 24 hours with TGF-β indicates participation of the hepatocyte detoxification system in this process by showing an up-regulation of ph…