Monitoring of liver cell transplantation by MRI
N Raschzok, N Billecke, A Zielinski, K Steinz, NN Kammer, S Schmeisser, MH Morgul, MK Adonopoulou, J Pinkernelle, J Unger, L Morawietz, B Hiebl, W Rüdinger, U Teichgräber, IM Sauer · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aim: Liver cell transplantation (LCT) is a promising approach for treating certain liver diseases. However, monitoring of LCT is challenging. Labelling with micron-sized iron oxide particles (MPIO) enables detection of cells by magnetic resonance imaging (MRI). Aim of this study was to investigate the feasibility of non-invasive monitoring of LCT by MRI in a preclinical large animal model. Materials & Methods: Porcine liver cells were labelled with MPIO and investigated in vitro. Detection threshold was determined under conditions of abdominal MRI. Labelled cells, native cells, or pure particles were transplante…
