MPA treatment of liver transplant patients may promote allograft tolerance in the long-term
V Cicinnati, J Hou, M Lindemann, PA Horn, CG Klein, G Sotiropoulos, A Paul, G Gerken, S Beckebaum · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Mycophenolate mofetil (MMF) is converted in the liver by ester hydrolysis to its active metabolite mycophenolic acid (MPA). Dendritic cell (DC) trafficking after organ transplantation constitutes an essential component in the process of allograft rejection. We investigated the effects of MPA on human blood myeloid DC (MDC) homeostasis with a particular emphasis on their trafficking properties. Methods: Isolated peripheral blood mononuclear cells (PBMC) from healthy donors were cultured with MPA for 48 hours without the addition of exogenous growth factors. Flow cytometry was used for phenotypic and functio…
