Reduced Bone Mineral Density in Wilson Disease

Introduction: Wilson disease (WD) is an inherited disorder of human copper metabolism. Remarkable findings in WD are various skeletal changes including demineralization, subarticular cysts, and marginal fragmentation, which have been reported in Wilson disease ranging from mild to severe. Recent studies suggested a high prevalence of osteoporosis up to 43% to 68%. Risk factors for the development of osteoporosis in WD are unknown. Patients and Results: This study concerns 151 patients examined at the University Heidelberg between 1990 and 2009. Bone mineral density (BMD) measurements were performed at presentati…