Indications of IL1β, IL18 and VEGF cascade in maintenance of homeostasis following transient pulmonary inflammation due to carbon nanoparticle (CNP) challenge in mice

Aims: Carbonaceous nanoparticles possess an emerging source of human exposure. The pulmonary inflammation caused by deposited nanoparticles is a key event for their adverse health effects. Epidemiological studies suggest that individuals with favourable lung physiology are at lower risk for particulate matter associated respiratory diseases. We selected a mouse strain C3H/HeJ (C3) with robust lung physiology and exposed it to moderately toxic carbon nanoparticles (CNP) to study the elicited pulmonary inflammation and its resolution. Methods: 5µg, 20µg and 50µg CNP were intratracheally (i.t.) instilled in C3 mice…