Macrophages promote proliferation of lung cancer cell by activation of NF-κB

Tumor-associated macrophages (TAMs) have been shown to promote tumor development including the growth, survival, invasion and metastasis of tumor cells. Cigarette smoke is a risk factor for a number of lung diseases including carcinogenesis, chronic obstructive pulmonary disease (COPD) by inducing an inflammatory response in the lung. Clinical studies have shown that patients with lung cancer who stop smoking have longer survival rate compared to patients who continue to smoke. The aim of the study was to demonstrate if macrophages promote proliferation of lung cancer cell and whether NF-κB activation is respons…