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Melatonin-insulin interactions in type 1 diabetic rats

E Peschke, I Stumpf, K Hofmann, S Streck, E Albrecht, S Wolgast, D Wedekind, E Mühlbauer · Klinische Neurophysiologie · 2010 · Heft 03

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974623
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Jahr
2010
Publikation
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DOI
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Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
E Peschke, I Stumpf, K Hofmann, S Streck, E Albrecht, S Wolgast, D Wedekind, E Mühlbauer
Ausgabe
Heft 03 / 2010
Seiten
–
Erschienen: 2010-03-02 00:00:00
ISSN
1434-0275
DOI
10.1055/s-0030-1250853

Zusammenfassung

Introduction: Melatonin receptors (MT1 and MT2) in pancreatic β-cells and both the adenylyl-cyclase-cAMP and guanylyl-cyclase-cGMP pathways are prerequisites for the well-known suppression of insulin secretion by melatonin. We found reduced melatonin plasma levels in type 2 diabetic patients as well as in type 2 diabetic Goto Kakizaki (GK) rats, a model of non-insulin-dependent diabetes mellitus (NIDDM). Previous studies have investigated the differences in glucose, insulin and melatonin levels in type 2 diabetic rats and humans. Moreover, expression of pineal insulin receptor (InsR)- and arylalkylamine-N-acetyl…

Schlagworte

Klinische Neurophysiologie