Efficiency of droxydopa in pure autonomic failure

Neurogenic orthostatic hypotension (OH) is the main symptom of generalized autonomic failure and often a first sign of pure autonomic failure (PAF). It involves chronic failure of the autonomic nervous system, characterized by orthostatic reduction of blood pressure and sympathetic denervation of the cardiovascular system, but also of the sudomotor and neuroendocrine regulation. The presence of Lewy bodies in autonomic ganglia indicates an alpha-synucleinopathy with exclusive affection of the peripheral nervous system. Reduced serum noradrenaline concenctrations are found, pointing towards dysregulation of norad…