Successful treatment of postanoxic generalized myoclonus with propofol – The prognosis remains poor

Background: There is evidence from single patients that propofol may control generalized myoclonus (GM) after cardiopulmonary resuscitation (CPR). Methods: Sixty consecutive patients, who developed GM within 24 hours after CPR, were treated with propofol. A starting dose of intravenous propofol (1mg/kg body weight) was followed by continuous infusion adjusted to suppress GM (80 to 250mg/h). Doses were re-evaluated every day. Determinations regarding the level of care to be provided were made 4 days after CPR in 19 patients surviving up to this point. Results: A single dose of intravenous propofol always suppress…