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Modulation of circulating human Alpha-2-HS-glycoprotein by FFAs

K Mai, T Bobbert, J Andres, A Assmann, F Reinecke, M Möhlig, A Pfeiffer, J Spranger · Diabetologie und Stoffwechsel · 2010 · Heft 04

Dokument
974847
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
K Mai, T Bobbert, J Andres, A Assmann, F Reinecke, M Möhlig, A Pfeiffer, J Spranger
Ausgabe
Heft 04 / 2010
Seiten
–
Erschienen: 2010-04-21 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0030-1253783

Zusammenfassung

Objective: The liver-secreted protein Alpha-2-HS-glycoprotein (AHSG) induces insulin resistance in animals, and circulating AHSG is elevated in insulin resistance and fatty liver in humans. Given that effect of free fatty acids (FFA) on insulin resistance, we hypothesized that free fatty acids, might increase insulin resistance by modification of AHSG. Research design and methods: Within a randomized placebo-controlled trial the effects of PPARa stimulation by free fatty acids were studied during supraphysiological FFA (sLHI) elevation in 17 healthy subjects (13 women and 4 men) and during physiological elevated…

Schlagworte

Diabetologie und Stoffwechsel