Treating to target in type 2 diabetes (4-T) study: 3-year results

Aims: Type 2 diabetes mellitus is a progressive condition in which glycated hemoglobin levels rise over time as beta-cell function declines. Maintenance of near-normal glycaemia reduces the risk of diabetic complications, but is difficult to achieve despite the use of multiple oral antidiabetic agents. As a result, oral therapy requires repeated escalation with the majority of patients requiring insulin in the longer term. There is, however, considerable uncertainty as to which insulin regimen should be used, Whether therapy should commence with the addition of a biphasic, a long-acting or a short-acting insulin…