TNFalpha and LPS – mediated inflammatory response in adipocytes and macrophages is attenuated by direct activation of angiotensin type 2– receptors

Angiotensin II exerts its effects through two different receptor subtypes: the AT1-receptor (AT1R) and the AT2-receptor (AT2R). The functional role of the AT1R in the development of insulin resistance (IR) is well understood, whereby AT1R blockers (ARBs) improve glucose intolerance and insulin resistance. In contrast, the role of the AT2 receptor in the regulation of glucose and lipid metabolism is still not clear. To determine the functional significance of AT2R stimulation in the development of IR and adipose tissue inflammation, we used the first non-peptide selective AT2R agonist, Compound 21 (C21), in an in…