CareLit Fachartikel

Expression and functional role of miR-200c in rhabdomyosarcoma

D Herrmann, G Seitz, S Warmann, M Bonin, I Leuschner, J Fuchs, S Armeanu-Ebinger · Klinische Pädiatrie · 2010 · Heft 05

Dokument
974892
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
D Herrmann, G Seitz, S Warmann, M Bonin, I Leuschner, J Fuchs, S Armeanu-Ebinger
Ausgabe
Heft 05 / 2010
Seiten
–
Erschienen: 2010-05-07 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0030-1254473

Zusammenfassung

Background: Aberrant microRNA (miRNA) expression is involved in the pathogenesis and progression of human malignancies, including embryonal tumors. Specific miRNA-levels may also serve as informative biomarkers of disease. The aim of this study was to identify specific miRNAs for different pediatric soft tissue sarcomas. Methods: We analyzed the expression of 750 miRNAs in 6 alveolar rhabdomyosarcoma (ARMS) and 6 malignant rhabdoid tumor (MRT) FFPE-tissue sections using an Illumina BeadArray. Stable expression of miR-200b and miR-200c in RMS cells was achieved by transfection of plasmids and by selection for res…

Schlagworte

Klinische Pädiatrie