Polymorphisms 1558 C>T in the Aromatase Gene (CYP 19A1) in Low-Grade Endometrial Stromal Sarcoma

Background: Low-grade endometrial stromal sacomas (ESS) are estrogen sensitive tumors. Polymorphic variation in the CYP19 gene can affect estrogen synthesis by increasing aromatase activity resulting in elevated levels of estrone and estradiol. We examined the polymorphism 1558 C>T in the aromatase gene (CYP 19A1) in a series of 20 low-grade endometrial stromal sarcomas. Methods: Archival formalin-fixed and paraffin-embedded material was analyzed with a fast real-time PCR system. Results: The heterozygous genotype C/T was detected in 10/20 (50%) and the homozygous genotype C/C in 3 (15%) of ESS. A polymorphism 1…