Pseudomonas aeruginosa acquisition in cystic fibrosis: a role for surfactant protein D and mannose-binding lectin?

Background: Pseudomonas aeruginosa (PSA) infection is one of the most relevant cause of morbidity and mortality in patients with cystic fibrosis (CF). Pulmonary collectins such as surfactant protein D (SP-D) and mannose-binding lectin (MBL) play critical role in local innate immunity and response to bacterial airway infections. Objective: We thus aimed to determine whether serum levels and functional relevant genetic variants of SP-D and MBL are associated with PSA infection susceptibility in patients with CF. Methods: We conducted a retrospective analysis for 42 children with CF and homozygous for DF508 allele.…