Activation of human immune cells by the oncolytic parvovirus H-1 combined with chemotherapeutic or targeted agents

Oncolytic viruses, such as autonomous parvoviruses (PV) and their therapeutic vectors are known to stimulate potent antitumoral immune responses in vitro and in vivo. The parvovirus H-1 efficiently infects and lyses human tumor cells, including human melanoma, hepatoma, colon- and gastric cancer cells. The aim of our research project was now to further evaluate the biologic and immunologic effects of H-1PV-induced tumor cell lysis (TCL) and its combination with chemotherapeutic and molecular targeted agents in two human melanoma models with adjacent characterized human cytotoxic T cells (CTL) and HLA-A2 restrict…