CareLit Fachartikel

CEACAM6 gene variants in inflammatory bowel disease

J Glas, J Seiderer, C Fries, T Ochsenkühn, B Göke, J Diegelmann, S Brand · Zeitschrift für Gastroenterologie · 2010 · Heft 08

Dokument
975129
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
J Glas, J Seiderer, C Fries, T Ochsenkühn, B Göke, J Diegelmann, S Brand
Ausgabe
Heft 08 / 2010
Seiten
–
Erschienen: 2010-08-03 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1263683

Zusammenfassung

Background and Aims: The carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) acts as a receptor for adherent-invasive E. coli (AIEC) and its ileal expression is increased in patients with Crohn's disease (CD). Given its contribution to the pathogenesis of CD, we aimed to investigate the role of genetic variants in the CEACAM6 region in patients with inflammatory bowel diseases (IBD). Methods: In this study, a total of 2683 genomic DNA samples (including DNA from 858 CD patients, 475 patients with ulcerative colitis (UC), and 1350 healthy, unrelated controls) was analyzed for eight CEACAM6 SNPs (r…

Schlagworte

Zeitschrift für Gastroenterologie