Tacrolimus in ulcerative colitis – extended three center experience
KJ Schmidt, K Fellermann, J Emmrich, D Barthel, D Thomas, H Koc, H Lehnert, J Büning, EF Stange, KR Herrlinger · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: In steroid-refractory or dependent attacks of ulcerative colitis (UC) tacrolimus has been shown to be beneficial although its long term efficacy remains unclear. Furthermore, the need of concomitant immunosuppression is ill defined. Objectives: Aim of this three center retrospective analysis was to evaluate efficacy and safety of tacrolimus in moderately to severely active UC for induction and maintenance of remission. Primary endpoints were short term response and colectomy free survival. Secondary outcome data were safety and tolerability. Methods: Charts of 161 patiens with steroid-dependent or -refract…
