Comparative evaluation of fecal calprotectin and S100A12 as non-invasive markers for disease activity in inflammatory bowel disease

Introduction: This study was aimed to evaluate the diagnostic accuracy of fecal S100A12, and fecal calprotectin in adult patients with irritable bowel syndrome (IBS) and active or inactive inflammatory bowel disease (IBD). As some authors suppose the use of higher cutoff levels for an improved discrimination of active from inactive IBD, different cutoff-levels were compared with endoscopic disease activity. Methods: Fecal levels of calprotectin and S100A12 were assessed by enzyme linked immunosorbent assay in 210 patients (78 IBS patients, 54 with UC, and 78 with 43 CD). The performance of each marker with refer…