Interstrain differences in susceptibility to non-alcoholic steatohepatitis

Non-alcoholic fatty liver disease (NAFLD) encompasses a clinico-pathologic spectrum of conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). The latter is widely considered as the first relevant pathophysiological step in NAFLD-progression, and epidemiological studies clearly indicate strong variation in the natural course of NAFLD in different ethnic groups. The aim of this study was to assess whether there are also differences in the susceptibility to NASH between different mouse strains. Methods and Results: Male C57BL/6, 129/SvJ and BALB/C mice (8 weeks old) were fed with high-fat…