HGF/c-Met signaling in hepatocytes protects against progression of chronic liver fibrosis
JU Marquardt, K Uchida, MC Gillen, D Seo, P Kaposi-Novak, EA Conner, VM Factor, SS Thorgeirsson · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
HGF/c-Met signaling plays a pivotal role in hepatocyte survival and tissue remodeling during liver regeneration. Treatment with HGF accelerates the resolution of fibrotic liver lesions in experimental animal models. To formally address the importance of c-Met signaling in hepatocytes in the context of chronic liver damage, we have used a model of chronic liver fibrosis in hepatocyte specific Metfl/fl;Alb-Cre±conditional knockout mice (KO). CCl4 was administrated biweekly over 4 weeks (injury phase) and animals were followed for the next 4 weeks (healing phase). Macroscopic and microscopic changes during both pha…
