Mass spectrometry based metabolomics to study the development of Non-alcoholic steatohepatitis

It can be hypothesized that the development of non-alcoholic steatohepatitis (NASH) is accompanied by severe changes at the metabolic level. Studying the metabolome may reveal insights in the underlying mechanisms leading from steatosis to the development of NASH and its progression to cirrhosis. Metabolomics attempts the comprehensive and quantitative analysis of metabolites in a biological system. Two complementary approaches are used for metabolomic investigations: metabolic fingerprinting and metabolic profiling. Metabolic fingerprinting aims to identify patterns or “fingerprints“ of metabolites, which chang…