Iron metabolism in patients with ALD
I Ganzleben, G Millonig, T Longerich, P Schirmacher, HK Seitz, HK Seitz, S Mueller · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Alcoholic liver disease (ALD) is the major liver disease in the developed world that is characterized by pathological hepatic iron deposits. This non-HFE-related iron overload is considered a key mechanism of rapid disease progression towards liver cirrhosis and hepatocellular carcinoma. We here performed a systematic histological, protein and mRNA expression analysis on liver biopsies from patients with well characterized ALD. Methods: 100 with histologically confirmed ALD were included. Clinical parameters, liver biopsies and serum iron parameters were collected. Histology and iron content were assessed…
