The role of cytochrome P-4502E1 in the development of hepatic fat, fibrosis and DNA lesions in patients with of alcoholic liver disease (ALD) and non-alcoholic fatty liver disease…
H Qin, K Glassen, G Millonig, KB Linhart, H Bartsch, XD Wang, S Mueller, HK Seitz · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Although the pathogenesis of alcoholic liver disease (ALD) is still unclear, there is increasing evidence of the involvement of cytochrome P-4502E1 (CYP2E1) in its progression, since the inhibition of CYP2E1 in animal experiments prevents ALD. In addition, CYP2E1 seems also responsible for the generation of carcinogenic DNA lesions in both ALD and NAFLD. The purpose of this study was to further investigate the role of CYP2E1 in hepatic steatosis, fibrosis and carcinogenesis in human livers. Methods: The degree of fat, fibrosis and CYP2E1 induction was determined in liver biopsies from 60 patients with vari…
