E-/ N-cadherin cis-heterodimer-bearing puncta adhaerentia as a hallmark for epithelia and derived tumors of the hepatopancreaticobiliary system
BK Straub, J Boda-Heggemann, UF Pape, R Zimbelmann, S Rickelt, C Grund, C Kuhn, S Singer, P Schirmacher, WW Franke · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Cell-cell junctions play a pivotal role in cell development and in cell functions, but also in tumor formation and progression. Cadherins, transmembrane glycoproteins of adherens junctions (AJs), such as the epithelial E-cadherin and the neural/ mesenchymal N-cadherin, are widely believed to act in a homophilic, tissue-specific manner and are attributed mutually exclusive roles in development, as well as in carcinogenesis and metastasis. Hitherto only E-cadherin has been described in AJ of normal hepatocytes. Yet, in previous work we could show that large amounts of both E- and N-cadherin are found in the same p…
