A seven gene signature (cirrhosis risk score) predicts recurrence of severe liver fibrosis after liver transplantation for hepatitis C infection
NT Cabral do Ó, D Eurich, P Schmitz, M Schmeding, M Bahra, P Neuhaus, C Trautwein, UP Neumann, HE Wasmuth · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Fibrosis recurrence after liver transplantation (LT) for hepatitis C (HCV) infection is a common event and a major determinant of the patients’ prognosis. The risk factors responsible for fibrosis progression post-LT are not well defined. We here assess whether a genetic risk score which predicts the progression of HCV induced fibrosis pre-LT is also associated with the development of severe fibrosis post-LT. Methods: Overall, the genetic cirrhosis risk score (CRS), comprising allele variants in seven genes (AP3S2, AQP2, AZIN1, DEGS1, STXBP5L, TLR4, TRPM5), was calculated in 138 patients who underwent LT f…
