Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with Dendritic Cells pulsed by HBVsvp

Introduction: It is known that in chronic Hepatitis B Virus (HBV) carriers the function of dendritic cells (DC) as well as the function of T-cells and B-cells is impaired. Within HBV transgenic mice no immune response against HBV is found due to central and peripheral tolerance. We recently showed that it is possible to activate DC of mice in vitro by pulsation with HBV sub viral particles (HBVsvp) and that by immunizing mice with such activated DC specific anti HBV directed immune responses are induced on cellular and humoral level. Aim of the study: In the present study we used HBV transgenic mice to observe i…