Clinical Goals of Targeted Therapy in Childhood ALL
M Schrappe, A Möricke, A Schrauder, G Cario, G Mann, MG Valsecchi, M Zimmermann, M Stanulla, V Conter · Klinische Pädiatrie · 2010 · Heft 12
Bibliografische Angaben
Zusammenfassung
Prospective clinical trials in childhood ALL have established robust prognostic parameters but, more importantly, they succeeded to reduce disease recurrence and to limit acute and late side effects. Prospective assessment of individual treatment response has demonstrated unequivocally that in vivo sensitivity may identify patients across all genetic subtypes with very distinct risk to relapse. Highly sensitive clonespecific PCR-based detection of minimal residual disease (MRD) in the recent trial AIEOP-BFM ALL 2000 identified approximately 40% of Bpc-ALL and 16% of T-ALL patients with fast clearance of disease.…
