The role of IL-22 in allergic airway disease
N Dehzad, C Tertilt, G Gyülveszi, K Kreymborg, K Schneeweiß, E Michel, S Reuter, H Martin, JC Renauld, R Buhl, B Becher, C Taube · Pneumologie · 2011 · Heft 02
Bibliografische Angaben
Zusammenfassung
The effector cytokine IL-22 produced by Th17 cells acts mainly on epithelial cells. For this cytokine both pro- and anti-inflammatory effects are reported. To assess the role of IL-22 in allergic airway disease C57BL/6 and IL22-deficient (IL-22–/–) mice were sensitized with ovalbumine (OVA) on days 0 and 14 and challenged with OVA aerosol on days 28–30. 24h after the last challenge inflammation and airway reactivity were analyzed. Treatment of C57BL/6 mice with rIL-22 before each airway challenge was performed to assess therapeutic effects of this cytokine. Following exposure to allergen lungs of sensitized and…
