The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia1
M Witzenrath, F Pache, D Lorenz, U Koppe, B Gutbier, K Meixenberger, C Tabeling, A Dorhoi, J Ma, A Holmes, G Trendelenburg, MM Heimesaat, S Bereswill, M van der Linden, J Tschopp, TJ Mitchell, N Suttorp, B Opitz · Pneumologie · 2011 · Heft 02
Bibliografische Angaben
Zusammenfassung
Streptococcus pneumoniae is a leading cause of pneumonia, meningitis and sepsis. While certain pneumococcal serotypes are associated with nasopharyngeal colonization, infections in patients with underlying diseases, and higher mortality when causing pneumonia, serotypes 1, 7F and 8 are predominantly found in invasive diseases that, however, show lower case-fatality rates. We tested the hypotheses that the innate immune inflammasome pathway is involved in fighting pneumococcal pneumonia, and that some invasive pneumococcal serotypes are not recognized by this pathway. We show that human and murine mononuclear cel…
