Bile proteomic profiles differentiates cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis

Introduction: Early detection of malignant biliary tract diseases, especially cholangiocarcinoma (CC) in patients with primary sclerosing cholangitis (PSC), is very difficult and often comes too late to give the patient a therapeutic benefit. Endoscopic diagnostic procedures are performed in clinical routine, but imaging methods, biopsies or brush cytology results are not sensitive enough to diagnose CC. Bile analysis obtained during endoscopic procedures as a diagnostic tool has not been studied so far. We hypothesize that bile proteomic analysis distinguishes CC from non-malignant lesions. Methods: We used cap…