Job Strain, Inflammatory Biomarkers and Coronary Events in Healthy Workers of the MONICA/KORA Augsburg Case-Cohort Study

Whether job strain contributes to the aetiology of coronary heart disease (CHD) is uncertain, and mechanisms underlying this relationship unknown. We investigated associations between job strain and biomarkers of subclinical inflammation and endothelial dysfunction with CHD, and examined whether these biomarkers provide mechanistic links between job strain and CHD. Study participants (n=1,027; age 35–64, 68% male) were selected from employed participants of the prospective, population-based MONICA/KORA Augsburg study (1984–2002). The case-cohort sample contained 951 non-cases and 114 incident CHD cases. Work str…