Internal segment of globus pallidum leads cortex during error detection: evidence from invasive electrophysiological recordings in dystonia patients

Introduction:Learning new motor tasks requires the ability to monitor ongoing behavior, detect errors and modify the performance accordingly. The generators of the corresponding ERP (error-related negativity, ERN) have been localized in the posterior frontomedian cortex (pFMC) that is intimately connected with the basal ganglia. However, the specific role of the basal ganglia in error-detection, as well as the interaction of the BG with the cortical regions during error-processing remains unclear. Here, we aim to investigate the modulation of neuronal activity in the internal segment of the globus pallidum (GPi)…