Plasmapheresis therapy in children with inflammatory demyelinating disorders of the CNS

Inflammatory demyelinating disorders of the CNS in children are treated with high dose steroids. If symptoms persist, more invasive treatment options are recommended. We discuss two patients: one with acute transverse myelitis and one with chronic relapsing remitting Multiple Sclerosis. A 9 year old boy presented with monoparesis of the left leg after influenza vaccination. Despite pulse steroid therapy clinical symptoms progressed to tetraparesis and affection of the respiratory function. MRI showed first extensive, then complete myelitis of the spinal cord without brain involvement. Cerebrospinal fluid showed…