Non-selective side effects of non-receptor tyrosine kinase inhibitors (TKI)

Aims: As shown before, TKI treatment impairs bone metabolism in patients with CML. In an ongoing study we investigated the TKI influence on the growing skeleton in juvenile rodents. Methods: Juvenile rats were chronically exposed to varying concentrations and different application schedules of TKI for a 10 week period starting after weaning at an age of 4 weeks. Animals were sacrificed at fixed time points after drug exposure to analyze the following parameters: bone length, bone mass density and biochemical parameters (PINP, testosterone, growth hormone, CTX-1, osteocalcin, TRAP). Results: Animals exhibited red…