CareLit Fachartikel

Sorafenib as a new therapeutic option for Hepatoblastoma

A Dewerth, C Eicher, J Fuchs, S Armeanu-Ebinger · Klinische Pädiatrie · 2011 · Heft 05

Dokument
976380
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
A Dewerth, C Eicher, J Fuchs, S Armeanu-Ebinger
Ausgabe
Heft 05 / 2011
Seiten
–
Erschienen: 2011-05-05 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0031-1277083

Zusammenfassung

Background: A developing multidrug resistance during chemotherapy constitutes for the poor responsiveness in patients with advanced Hepatoblastoma (HB). The multikinase inhibitor sorafenib may stand for a new therapeutic approach. Methods: To evaluate the effect of sorafenib on different HB cell lines MTT-/Caspase 3-Assay was performed. Sorafenib was administered orally to NMRI mice bearing HUH6 tumors. Tumor progression was determined by tumor volume and AFP levels. Angiogenesis and apoptosis in the tumor tissue were detected by CD31-staining and TUNEL-assay, respectively. Results: Cell viability in HB cell lin…

Schlagworte

Klinische Pädiatrie