Effect of different dose cannabidiol treatment on experimental induced colitis

Introduction: Cannabidiol (CBD) may exert beneficial effects in intestinal inflammation and cancer because of its antiproliferative, antimetastatic and apoptotic effects as well as reducing cytokine release and promoting wound healing via activation of CB1 and/or CB2 receptors. Pharmacological elevation of endocannabinoid levels may be a promising strategy to counteract intestinal inflammation. Aims: Our aims were to investigate the effect of different dose cannabidiol on experimentally induced colitis to evaluate its moderation of free radical reactions. Material and methods: Male Wistar rats (200–250 bwg) were…