Diabetes mellitus is more common in chronic hepatitis C patients and is a negative predictor for sustained virological response. Results of a study from a north-east Hungarian reg…

Background: The prevalence of type 2 diabetes mellitus (T2DM) is higher in chronic hepatitis C (CHC) patients compared to healthy population. Hepatitis C virus (HCV) can directly influence the intracellular insulin signaling pathway (ISP), and causes elevation in serum level of pro-inflammatory cytokins such as TNF-α or IL-6. Diabetes is considered a negative predictor for the success of the antiviral therapy. Aim: We analyzed the prevalence of the T2DM and it's impact for the sustained virological response (SVR) and other abnormalities of carbohydrate metabolism in CHC patients from North-East Hungary (NEH). Pa…