Importance of oxyphil cells for 99mTc-sestamibi uptake in primary hyperparathyroidism: a retrospective observational study
Jan Axl Dropmann, Axel Kleespies, Heinrich Fuerst, Marcus Kremer, Moritz Drefs, Michael Neuberger · Nuklearmedizin - NuclearMedicine · 2025 · Heft 03 · S. 215-224
Bibliografische Angaben
Zusammenfassung
Abstract Aims In patients with primary hyperparathyroidism (pHPT), the importance of oxyphil cells for 99mTc-sestamibi uptake is uncertain. Methods This retrospective observational study of pHPT patients evaluated independent associations between oxyphil cell content (OCC) and preoperative scintigraphic (SC) findings, using logistic regression analyses. Results We studied 76 patients with pHPT before and after operation. Preoperative SC was able to definitively identify abnormal parathyroid tissue in 47 patients (61.8%). The median relative OCC (postoperative histopathological examination) was 10% (IQR 0.25% – 4…
