Prognostic Significance of CD68+ Macrophages and FoxP3+ Regulatory T Cells in Neuroendocrine Tumors
Barbara Kreppel, Jana Fink, Christine Sanders, Anna Scherping, Oliver Hommerding, Milka Marinova, Ingo G. H. Schmidt-Wolf, Georg Feldmann, Maria Angeles Gonzalez-Carmona, Azin Jafari · Nuklearmedizin - NuclearMedicine · 2026 · Heft 01 · S. 39-47
Bibliografische Angaben
Zusammenfassung
Abstract Aim Neuroendocrine tumors (NETs) are a heterogeneous group of malignancies characterized by variable immune microenvironment. This study aimed to analyze the infiltration of NETs by CD68+ tumor-associated macrophages (TAMs) and FoxP3+ regulatory T cells (Tregs) using Qupath software for semi-automated histopathological quantification Methods Thirty-two patients with resected NETs were included. CD68 and FoxP3 expression were assessed by immunohistochemistry followed by automated cell detection and spatial analysis. Results The mean percentage of CD68+ cells was 0.35%, with no significant differences bet…
