Diagnostic Value of Maternal Zonulin Levels in Fetal Growth Disorders

Abstract Background Zonulin, a biomarker linked to intestinal barrier dysfunction, may contribute to fetal growth disorders such as intrauterine growth restriction (IUGR) and small-for-gestational-age (SGA) pregnancies. This study evaluated maternal serum zonulin levels as a diagnostic tool for distinguishing IUGR from SGA and investigated their associations with perinatal outcomes. Methods This cross-sectional study included singleton pregnancies between 32 and 37 weeks. Maternal blood samples collected at 16–18 weeks of gestation were analyzed for serum zonulin levels using ELISA, with measurements performed a…