Difficult-to-interpret dopamine transporter SPECT with [123I]ioflupane in the diagnosis of parkinsonism
Loren Jedid, Susanne Klutmann, Rickmer Braren, Philipp T Meyer, Ralph Buchert · Nuklearmedizin - NuclearMedicine · 2026 · Heft 02 · S. 83-92
Bibliografische Angaben
Zusammenfassung
Abstract Aim To estimate (i) the rate of difficult-to-interpret cases in dopamine transporter (DAT)-SPECT with [123I]ioflupane and (ii) the diagnostic accuracy of binary visual categorization in difficult-to-interpret DAT-SPECT. Methods The study included 178 control subjects (49% females, 63.7±11.7y) and 178 sex- and age-matched patients with pre-screening clinical diagnosis of Parkinson’s disease (PD) from the Parkinson’s Progression Markers Initiative (PPMI). SPECT images reconstructed by the PPMI and a local method were visually interpreted twice by 2 independent readers with respect to Parkinson-like reduct…
