Radioactive Gold Isotopes in the Era of Theranostics: Medical Potential of ¹⁹⁸Au and ¹⁹⁹Au Radioisotopes
Punita Bhardwaj, Guilhem Claude, Winfried Brenner, Sarah Spreckelmeyer · Nuklearmedizin - NuclearMedicine · 2026 · Heft 02 · S. 69-82
Bibliografische Angaben
Zusammenfassung
Abstract Aim Radioactive gold isotopes, particularly the element-matched theranostic pair 198Au and 199Au, hold significant promise for targeted radionuclide therapy and SPECT imaging. This review critically evaluates their medical potential by contextualizing historical development, nuclear properties, production physics, radiochemical separations, and contemporary radiopharmaceutical applications to identify pathways for clinical translation. Methods We comprehensively surveyed literature on gold isotope decay characteristics, reactor and accelerator based production from Au, Pt, and Hg targets, purification s…
