Endoscopic full-thickness resection in the colon using a clip and cut technique

Background: While endoscopic resection techniques have been established for definitive therapy of mucosal neoplasia, complete resection of deeper and subepithelial lesions is not reliably possible. To overcome these limitations a novel endoscopic full-thickness resection (EFTR) and closure technique was developed. Methods: in eight anesthetized female domestic pigs 2cm artificial colonic lesions were created endoscopically by circumferential electrocautery markings. EFTR of the lesions was attempted using a prototype device, which consists of a large transparent plastic cap with a pre-loaded snare and a modified…