CareLit Fachartikel
Quantitative assessment of the Septin9 biomarker for colorectal cancer recurrence monitoring
S Hiemer, M Krispin, J Lewin, S Payne, HJ Schmoll · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Dokument
977412
CareLit-ID
Jahr
2011
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zitierfähig
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Zusammenfassung
Purpose: DNA methylation biomarkers can be used to detect tumor-derived circulating DNA and diagnose colorectal cancer (CRC) in blood as demonstrated by the CE-marked Epi proColon for the detection of methylated-SEPT9 ( m SEPT9) in plasma. In addition to qualitative assessment of m SEPT9 for early detection, quantitative assessment of m SEPT9 could provide information to the physician following diagnosis. Materials and methods: m SEPT9 and methylated-RASSF2A were measured using quantitative-PCR on bisulfite-converted DNA from CRC patient plasma taken before and following surgery. A multi-center clinical study wa…
Schlagworte
Diagnosis
Biomarkers
Blood
After
Tumor
Zeitschrift für Gastroenterologie
