Phosphorylation of the novel PKD2 substrate ABI-1 prevents tumor cell migration

Members of Protein kinase D family (PKD1, -2, and -3), a subfamily of the CAMK super family are serine/threonine kinases that play an important position in the signal transduction pathways downstream of diacylglycerol (DAG) and protein kinase C (PKC). The three isoforms share striking similarities and have been implicated in regulation of multiple biological processes including proliferation, survival, apoptosis, angiogenesis, and motility. Important role of PKD's in each of these physiological and pathological processes further underscores the significance of identifying and characterizing novel PKD substrates.…