CareLit Fachartikel

Migration of hepatic CXCR4+ fibrocytes is directed by SDF-1 in Abcb4-/- mice

S Pasupuleti, C Neumann, A Tschuschner, E Roeb, M Roderfeld · Zeitschrift für Gastroenterologie · 2011 · Heft 08

Dokument
977443
CareLit-ID
Jahr
2011
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
S Pasupuleti, C Neumann, A Tschuschner, E Roeb, M Roderfeld
Ausgabe
Heft 08 / 2011
Seiten
–
Erschienen: 2011-08-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1285713

Zusammenfassung

Introduction: CXCR4 chemokine receptor plays a central role in mobilization and homing of stem cells. Its ligand SDF-1 (stromal derived factor-1, CXCL12) creates the gradient required for directed migration of bone marrow derived CXCR4+ fibrocytes in different organ diseases1. Recently we could show that CD34+ bone marrow derived fibrocytes play a crucial role in hepatic fibrogenesis in the BALB/c-ABCB4 -/- mouse model of sclerosing cholangitis2. With the current study we analyzed whether the migration of CD34+ fibrocytes from BALB/c-Abcb4 -/- mouse liver depends on the CXCR4-SDF-1 axis. Methods: Expression of C…

Schlagworte

Axis Chemokines Cholangitis Chemokine Movement Zeitschrift für Gastroenterologie