Effects of class-3 semaphorins on brain tumour progression

Malignant brain tumors belong to the most frequent tumor encountered in childhood. Standard treatment modalities are neurosurgical resection, chemotherapy and irradiation. In contrast to the excellent results of well established treatment studies in pediatric patients suffering from leukaemia cure rates of children with malignant brain tumors remained low. Therefore the development of new antitumor strategies has become a major assignment in experimental neurology. Class-3 semaphorins have been first identified as axon guidance factors and during the last years it was found that some are able to inhibit angiogen…