Evaluating fetal cord blood lipids and oxidized LDL status in intrauterine growth restriction and preeclampsia
U Pecks, B Schiessl, D Bauerschlag, N Maass, W Rath · Zeitschrift für Geburtshilfe und Neonatologie · 2011 · Heft 11
Bibliografische Angaben
Zusammenfassung
Ziel: Intrauterine growth restriction (IUGR) and preeclampsia (PE) affect 3–8% of pregnancies. Theunderlying causes are not fully understood. Maternal metabolic changes contribute to the pathogenesisin both, PE and IUGR. Whether a disturbed lipid metabolism and cholesterol supply affect the fetus withconsequences for fetal programming of cardiovascular diseases later in life remains to be clarified. Wehere evaluated fetal chord blood lipids in IUGR and PE and hypothesized a more atherogeniclipoprotein profile in IUGR fetuses. Methodik: Umbilical cord serum TC, LDL-C, HDL-C, and oxLDL concentrations of IUGR (n=28…